Having been befriended by Spider-Man on more than one account, the Punisher acts to protect his former ally when everyone seems intent on destroying him. Using his extensive training and utilizing and amazing military armory, the Punisher sets out to capture the mutated Spider-Man before any harm comes his way. But the Punisher's mission puts him face-to-face with not only normal citizens trying to destroy the mutated Spider-Man, but also with the ultimate hunter, Kraven!